Registries have shown it can take 7+ years to diagnose—would you recognize systemic mastocytosis?⁹

Skin lesions. Anaphylaxis. Diarrhea.^1,3

Either alone or in combination, these are the hallmark symptoms of systemic mastocytosis (SM) that commonly appear with unexplained persistence or recurrence.^1,3,4,9,10

Patients often present with 2 or more seemingly unrelated symptoms that may be driven by the KIT D816V mutation. The KIT D816V mutation is the central driver of systemic mastocytosis in ~95% of cases.^1,3,9-11

There are also 20+ possible symptoms that could signal mast cell involvement. In some cases, systemic mastocytosis can lead to organ damage and shortened overall survival.^5-8,12

Could KIT D816V be hiding in your practice? Learn more about uncovering this mutation, and find labs that test for KIT D816V using high-sensitivity assays.

References: 1. Gilreath JA, et al. Clin Pharmacol. 2019;11:77-92. 2. Theoharides TC, et al. N Engl J Med. 2015;373(2):163-172. 3. Hartmann K, et al. J Allergy Clin Immunol. 2016;137(1):35-45. 4. Shomali W, Gotlib J. Hematology Am Soc Hematol Educ Program. 2018(1):127-136. 5. Lim KH, et al. Blood. 2009;113(23):57‌27‌-‌57‌36. 6. Kibsgaard L, et al. Derm. 2020;6:294-300. 7. Sperr WR, et al. Lancet Haematol. 2019;6(12):e638-e649. 8. Trizuljak J, et al. Allergy. 2020;75(8):1927-1938. 9. Jennings SV, et al. Immunol Allergy Clin North Am. 2018;38(3):505-525. 10. Garcia-Montero AC, et al. Blood. 2006;108(7):23‌66‌-‌23‌72. 11. Verstovsek S. Eur J Haematol. 2013;90(2):89-98. 12. van Anrooij B, et al. Allergy. 2016;71(11):1585-1593.

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